TTC3

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.[5][6]

TTC3
Identifiers
Aliases	TTC3, DCRR1, RNF105, TPRDIII, tetratricopeptide repeat domain 3
External IDs	OMIM: 602259 MGI: 1276539 HomoloGene: 2487 GeneCards: TTC3
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.13 Start 37,073,226 bp[1] End 37,203,112 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C4|16 55.18 cM Start 94,370,618 bp[2] End 94,469,343 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • metal ion binding • ubiquitin-protein transferase activity • transferase activity Cellular component • nucleolus • cell nucleus • cytosol Biological process • protein K48-linked ubiquitination • protein ubiquitination • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7267	22129
Ensembl	ENSG00000182670	ENSMUSG00000040785
UniProt	P53804	O88196
RefSeq (mRNA)	NM_001001894 NM_003316 NM_001320703 NM_001320704 NM_001330681 NM_001330682 NM_001330683 NM_001353936 NM_001353937 NM_001353938	NM_009441
RefSeq (protein)	NP_001001894 NP_001307632 NP_001307633 NP_001317610 NP_001317611 NP_001317612 NP_003307 NP_001340865 NP_001340866 NP_001340867	XP_011249721.1 XP_011249722.1 XP_011249724.1 XP_011249725.1 XP_011249730.1 XP_011249731.1 XP_011249732.1 XP_011249733.1
Location (UCSC)	Chr 21: 37.07 – 37.2 Mb	Chr 16: 94.37 – 94.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000182670 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040785 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem. 120 (4): 820–7. doi:10.1093/oxfordjournals.jbchem.a021485. PMID 8947847.
6. "Entrez Gene: TTC3 tetratricopeptide repeat domain 3".

Further reading

• Ohira M, Ootsuyama A, Suzuki E, et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi:10.1093/dnares/3.1.9. PMID 8724848.
• Eki T, Abe M, Naitou M, et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
• Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
• Rachidi M, Lopes C, Gassanova S, et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi:10.1016/S0925-4773(00)00259-8. PMID 10781955.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Berto G, Camera P, Fusco C, et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell Sci. 120 (Pt 11): 1859–67. doi:10.1242/jcs.000703. PMID 17488780.