TOR2A

Torsin-2A is a protein that in humans is encoded by the TOR2A gene.[5][6]

TOR2A
Identifiers
Aliases	TOR2A, TORP1, torsin family 2 member A
External IDs	OMIM: 608052 MGI: 1353596 HomoloGene: 25260 GeneCards: TOR2A
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.11 Start 127,731,524 bp[1] End 127,735,313 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 32,757,234 bp[2] End 32,762,244 bp[2]
Gene ontology Molecular function • ATP binding • nucleotide binding • ATPase activity • hormone activity Cellular component • endoplasmic reticulum lumen • endoplasmic reticulum • nuclear envelope • extracellular region Biological process • protein homooligomerization • chaperone mediated protein folding requiring cofactor • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of receptor activity • positive regulation of gene expression • vasopressin secretion • water homeostasis • positive regulation of calcium ion transmembrane transport • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27433	30933
Ensembl	ENSG00000160404	ENSMUSG00000009563
UniProt	Q5JU69 Q8N2E6	P0C7W3 Q8R1J9
RefSeq (mRNA)	NM_001085347 NM_001134430 NM_001134431 NM_001252018 NM_001252021 NM_001252023 NM_130459	NM_152800
RefSeq (protein)	NP_001078816 NP_001127902 NP_001127903 NP_001238947 NP_001238950 NP_001238952 NP_569726 NP_001127902.1	NP_690013 NP_001356151 NP_001356152 NP_001356153 NP_001356154
Location (UCSC)	Chr 9: 127.73 – 127.74 Mb	Chr 2: 32.76 – 32.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000160404 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009563 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ozelius LJ, Page CE, Klein C, Hewett JW, Mineta M, Leung J, Shalish C, Bressman SB, de Leon D, Brin MF, Fahn S, Corey DP, Breakefield XO (Mar 2000). "The TOR1A (DYT1) gene family and its role in early onset torsion dystonia". Genomics. 62 (3): 377–84. doi:10.1006/geno.1999.6039. PMID 10644435.
6. "Entrez Gene: TOR2A torsin family 2, member A".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shichiri M, Ishimaru S, Ota T, et al. (2003). "Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities". Nat. Med. 9 (9): 1166–72. doi:10.1038/nm913. PMID 12910263.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang Z, Takahashi T, Saito Y, et al. (2006). "Salusin beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1". Eur. J. Pharmacol. 539 (3): 145–50. doi:10.1016/j.ejphar.2006.03.064. PMID 16697365.