TOP3B

DNA topoisomerase 3-beta-1 is an enzyme that in humans is encoded by the TOP3B gene.[5][6][7]

TOP3B
Identifiers
AliasesTOP3B, TOP3B1, topoisomerase (DNA) III beta, DNA topoisomerase III beta
External IDsOMIM: 603582 MGI: 1333803 HomoloGene: 2923 GeneCards: TOP3B
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q11.22Start21,957,025 bp[1]
End21,982,816 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8940

21976

Ensembl

ENSG00000100038

ENSMUSG00000022779

UniProt

O95985

Q9Z321

RefSeq (mRNA)

NM_011624
NM_001326576

RefSeq (protein)

NP_001313505
NP_035754

Location (UCSC)Chr 22: 21.96 – 21.98 MbChr 16: 16.87 – 16.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000100038 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022779 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tang D, Kidd VJ (Dec 1998). "Cleavage of DFF-45/ICAD by multiple caspases is essential for its function during apoptosis". J Biol Chem. 273 (44): 28549–52. doi:10.1074/jbc.273.44.28549. PMID 9786842.
  6. Kawasaki K, Minoshima S, Nakato E, Shibuya K, Shintani A, Schmeits JL, Wang J, Shimizu N (May 1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi:10.1101/gr.7.3.250. PMID 9074928.
  7. "Entrez Gene: TOP3B topoisomerase (DNA) III beta".

Further reading


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