TMED4

Transmembrane emp24 domain-containing protein 4 is a protein that in humans is encoded by the TMED4 gene.[4][5]

TMED4
Identifiers
Aliases	TMED4, ERS25, HNLF, GMP25iso, p24alpha3, p24a3, transmembrane p24 trafficking protein 4
External IDs	OMIM: 612038 MGI: 1915070 HomoloGene: 5308 GeneCards: TMED4
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,577,894 bp[1] End 44,582,287 bp[1]
Gene ontology Molecular function • signal transducer activity Cellular component • integral component of membrane • extracellular exosome • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • protein transport • positive regulation of I-kappaB kinase/NF-kappaB signaling • signal transduction • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	222068	103694
Ensembl	ENSG00000158604	n/a
UniProt	Q7Z7H5	Q8R1V4
RefSeq (mRNA)	NM_182547 NM_001303058 NM_001303059 NM_001303060 NM_001303061 NM_001303062	NM_134020
RefSeq (protein)	NP_001289987 NP_001289988 NP_001289989 NP_001289990 NP_001289991 NP_872353	NP_598781
Location (UCSC)	Chr 7: 44.58 – 44.58 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000158604 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.
5. "Entrez Gene: TMED4 transmembrane emp24 protein transport domain containing 4".

Further reading

• Matoba R; Okubo K; Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S; Weil B; Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW; Cheung J; MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S; Arlt D; Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Otsuki T; Ota T; Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Mehrle A; Rosenfelder H; Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.