TJAP1

Tight junction-associated protein 1 is a protein that in humans is encoded by the TJAP1 gene.[5][6]

TJAP1
Identifiers
Aliases	TJAP1, PILT, TJP4, tight junction associated protein 1
External IDs	OMIM: 612658 MGI: 1921344 HomoloGene: 12534 GeneCards: TJAP1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,477,523 bp[1] End 43,506,556 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,257,851 bp[2] End 46,283,026 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cell junction • endosome • trans-Golgi network • cell membrane • bicellular tight junction • Golgi apparatus Biological process • Golgi organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	93643	74094
Ensembl	ENSG00000137221	ENSMUSG00000012296
UniProt	Q5JTD0	Q9DCD5
RefSeq (mRNA)	NM_001146016 NM_001146017 NM_001146018 NM_001146019 NM_001146020 NM_080604 NM_001350561 NM_001350562 NM_001350563 NM_001350564 NM_001350565 NM_001350566 NM_001350567 NM_001350568 NM_001350569 NM_001350570	NM_001252473 NM_001252474 NM_001252475 NM_028751
RefSeq (protein)	NP_001139488 NP_001139489 NP_001139490 NP_001139491 NP_001139492 NP_542171 NP_001337490 NP_001337491 NP_001337492 NP_001337493 NP_001337494 NP_001337495 NP_001337496 NP_001337497 NP_001337498 NP_001337499	NP_001239402 NP_001239403 NP_001239404 NP_083027
Location (UCSC)	Chr 6: 43.48 – 43.51 Mb	Chr 17: 46.26 – 46.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

TJAP1 has been shown to interact with DLG1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000137221 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000012296 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kawabe H, Nakanishi H, Asada M, Fukuhara A, Morimoto K, Takeuchi M, Takai Y (Dec 2001). "Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells". J Biol Chem. 276 (51): 48350–5. doi:10.1074/jbc.M107335200. PMID 11602598.
6. "Entrez Gene: TJAP1 tight junction associated protein 1 (peripheral)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Xavier R, Rabizadeh S, Ishiguro K, et al. (2004). "Discs large (Dlg1) complexes in lymphocyte activation". J. Cell Biol. 166 (2): 173–8. doi:10.1083/jcb.200309044. PMC 2172307. PMID 15263016.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.