THRAP3

Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.[5]

THRAP3
Identifiers
Aliases	THRAP3, TRAP150, thyroid hormone receptor associated protein 3, BCLAF2
External IDs	OMIM: 603809 MGI: 2442637 HomoloGene: 31289 GeneCards: THRAP3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 36,224,416 bp[1] End 36,305,357 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 126,164,082 bp[2] End 126,202,760 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GO:0001105 transcription coactivator activity • GO:0001104 transcription cofactor activity • thyroid hormone receptor binding • phosphoprotein binding • core promoter sequence-specific DNA binding • GO:0001948 protein binding • ligand-dependent nuclear receptor transcription coactivator activity • ATP binding • vitamin D receptor binding • receptor activity • RNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • signaling receptor activity Cellular component • nuclear speck • mediator complex • exon-exon junction complex • nucleoplasm • extracellular exosome • cell nucleus Biological process • androgen receptor signaling pathway • regulation of transcription, DNA-templated • positive regulation of mRNA splicing, via spliceosome • rhythmic process • mRNA processing • intracellular steroid hormone receptor signaling pathway • regulation of alternative mRNA splicing, via spliceosome • transcription, DNA-templated • positive regulation of transcription, DNA-templated • nuclear-transcribed mRNA catabolic process • mRNA stabilization • circadian rhythm • RNA splicing • positive regulation of circadian rhythm • transcription initiation from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9967	230753
Ensembl	ENSG00000054118	ENSMUSG00000043962
UniProt	Q9Y2W1	Q569Z6
RefSeq (mRNA)	NM_005119 NM_001321471 NM_001321473	NM_146153 NM_001356455 NM_001356456
RefSeq (protein)	NP_001308400 NP_001308402 NP_005110	NP_666265 NP_001343384 NP_001343385
Location (UCSC)	Chr 1: 36.22 – 36.31 Mb	Chr 4: 126.16 – 126.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000054118 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043962 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: THRAP3 thyroid hormone receptor associated protein 3".

Further reading

• Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. doi:10.1073/pnas.93.16.8329. PMC 38670. PMID 8710870.
• Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
• Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
• Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
• Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. doi:10.1038/417563a. PMID 12037571.
• Johnson KM, Wang J, Smallwood A, et al. (2002). "TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA". Genes Dev. 16 (14): 1852–63. doi:10.1101/gad.995702. PMC 186393. PMID 12130544.
• Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.