TCL1B

T-cell leukemia/lymphoma protein 1B is a protein that in humans is encoded by the TCL1B gene.[3][4]

TCL1B
Identifiers
Aliases	TCL1B, SYN-1, TML1, T-cell leukemia/lymphoma 1B, T cell leukemia/lymphoma 1B, TCL1 family AKT coactivator B
External IDs	OMIM: 603769 HomoloGene: 81735 GeneCards: TCL1B
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.13 Start 95,686,426 bp[1] End 95,692,628 bp[1]
Gene ontology Molecular function • protein kinase binding • protein serine/threonine kinase activator activity Cellular component • macromolecular complex Biological process • positive regulation of peptidyl-serine phosphorylation • positive regulation of protein serine/threonine kinase activity • positive regulation of cell proliferation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9623	n/a
Ensembl	ENSG00000213231	n/a
UniProt	O95988	n/a
RefSeq (mRNA)	NM_199206 NM_004918	n/a
RefSeq (protein)	NP_004909	n/a
Location (UCSC)	Chr 14: 95.69 – 95.69 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000213231 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (May 1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc Natl Acad Sci U S A. 96 (6): 2949–51. doi:10.1073/pnas.96.6.2949. PMC 15875. PMID 10077617.
4. "Entrez Gene: TCL1B T-cell leukemia/lymphoma 1B".

Further reading

• Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.
• Laine J, Künstle G, Obata T, et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
• Saitou M, Sugimoto J, Hatakeyama T, et al. (2000). "Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia". Oncogene. 19 (23): 2796–802. doi:10.1038/sj.onc.1203604. PMID 10851082.
• Sugimoto J, Hatakeyama T, Narducci MG, et al. (1999). "Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus". Cancer Res. 59 (10): 2313–7. PMID 10344735.