ELOA

Transcription elongation factor B polypeptide 3 is a protein that in humans is encoded by the TCEB3 gene.[5][6][7]

ELOA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HFX
Identifiers
Aliases	ELOA, EloA, SIII, SIII p110, TCEB3A, TCEB3, transcription elongation factor B subunit 3, elongin A
External IDs	OMIM: 600786 MGI: 1351315 HomoloGene: 37746 GeneCards: ELOA
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 23,743,155 bp[1] End 23,762,059 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 136,003,368 bp[2] End 136,021,763 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell nucleus • nucleoplasm • extracellular • elongin complex Biological process • transcription elongation from RNA polymerase II promoter • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6924	27224
Ensembl	ENSG00000011007	ENSMUSG00000028668
UniProt	Q14241	Q8CB77
RefSeq (mRNA)	NM_003198	NM_013736
RefSeq (protein)	NP_003189	NP_038764
Location (UCSC)	Chr 1: 23.74 – 23.76 Mb	Chr 4: 136 – 136.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis and is capable of forming a stable complex with elongins B and C. The von Hippel–Lindau tumor suppressor protein binds to elongins B and C and thereby inhibits transcription elongation.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000011007 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028668 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aso T, Mokady N, Haque D, Conaway RC, Conaway JW (Mar 1996). "Assignment of a human gene encoding the 110-kDa subunit of general transcription factor elongin (SIII) to chromosome 1p36.1". Genomics. 30 (2): 393–4. PMID 8586449.
6. Aso T, Lane WS, Conaway JW, Conaway RC (Oct 1995). "Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II". Science. 269 (5229): 1439–43. doi:10.1126/science.7660129. PMID 7660129.
7. "Entrez Gene: TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)".

Further reading

• Shilatifard A (1998). "Factors regulating the transcriptional elongation activity of RNA polymerase II". FASEB J. 12 (14): 1437–46. PMID 9806752.
• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Aso T, Haque D, Fukudome K, et al. (1996). "A human cDNA encoding the 110-kDa A subunit of RNA polymerase II transcription factor elongin". Gene. 168 (2): 277–8. doi:10.1016/0378-1119(95)00750-4. PMID 8654961.
• Pan G, Aso T, Greenblatt J (1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators". J. Biol. Chem. 272 (39): 24563–71. doi:10.1074/jbc.272.39.24563. PMID 9305922.
• Ohh M, Takagi Y, Aso T, et al. (2000). "Synthetic peptides define critical contacts between elongin C, elongin B, and the von Hippel-Lindau protein". J. Clin. Invest. 104 (11): 1583–91. doi:10.1172/JCI8161. PMC 481054. PMID 10587522.
• Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
• Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". J. Biomed. Sci. 9 (1): 82–96. doi:10.1007/BF02256581. PMID 11810028.
• Yamazaki K, Guo L, Sugahara K, et al. (2002). "Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3". J. Biol. Chem. 277 (29): 26444–51. doi:10.1074/jbc.M202859200. PMID 11994304.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tamura K, Miyata K, Sugahara K, et al. (2003). "Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain". Biochem. Biophys. Res. Commun. 309 (1): 189–95. doi:10.1016/S0006-291X(03)01556-0. PMID 12943681.
• Stoletov KV, Terman BI (2004). "Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation". Biochem. Biophys. Res. Commun. 320 (1): 70–5. doi:10.1016/j.bbrc.2004.05.134. PMID 15207703.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMC 1422157. PMID 16498413.