TARBP1

Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene.[4][5]

TARBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HA8
Identifiers
Aliases	TARBP1, TRM3, TRP-185, TRP185, TAR (HIV-1) RNA binding protein 1, TRMT3
External IDs	OMIM: 605052 MGI: 4936930 HomoloGene: 38082 GeneCards: TARBP1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.2 Start 234,391,313 bp[1] End 234,479,179 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • RNA methyltransferase activity • transferase activity • tRNA (guanine) methyltransferase activity • RNA binding • rRNA (guanosine-2'-O-)-methyltransferase activity Cellular component • cell nucleus Biological process • regulation of transcription from RNA polymerase II promoter • methylation • RNA processing • tRNA methylation • enzyme-directed rRNA 2'-O-methylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6894	212728
Ensembl	ENSG00000059588	n/a
UniProt	Q13395	E9Q368
RefSeq (mRNA)	NM_005646	NM_001159907
RefSeq (protein)	NP_005637	NP_001153379
Location (UCSC)	Chr 1: 234.39 – 234.48 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000059588 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Wu F, Garcia J, Sigman D, Gaynor R (Dec 1991). "tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185". Genes Dev. 5 (11): 2128–40. doi:10.1101/gad.5.11.2128. PMID 1936997.
5. "Entrez Gene: TARBP1 Tar (HIV-1) RNA binding protein 1".

Further reading

• Sheline CT, Milocco LH, Jones KA (1992). "Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin". Genes Dev. 5 (12B): 2508–20. doi:10.1101/gad.5.12b.2508. PMID 1752441.
• Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
• Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". J. Biol. Chem. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
• Wu-Baer F, Lane WS, Gaynor RB (1996). "The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA". EMBO J. 14 (23): 5995–6009. PMC 394719. PMID 8846792.
• Yedavalli VS, Benkirane M, Jeang KT (2003). "Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1". J. Biol. Chem. 278 (8): 6404–10. doi:10.1074/jbc.M209162200. PMID 12458222.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.