TAFA5

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene.[5][6]

TAFA5
Identifiers
AliasesTAFA5, QLLK5208, TAFA-5, UNQ5208, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, family with sequence similarity 19 member A5, C-C motif chemokine like, TAFA chemokine like family member 5, FAM19A5
External IDsOMIM: 617499 MGI: 2146182 HomoloGene: 22888 GeneCards: TAFA5
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.32Start48,489,460 bp[1]
End48,850,912 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

25817

106014

Ensembl

ENSG00000219438

ENSMUSG00000054863

UniProt

Q7Z5A7

Q91WE9

RefSeq (mRNA)

NM_015381
NM_001082967

NM_001252310
NM_134096

RefSeq (protein)

NP_001076436
NP_056196

NP_001239239
NP_598857

Location (UCSC)Chr 22: 48.49 – 48.85 MbChr 15: 87.54 – 87.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000219438 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054863 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
  6. "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 11 August 2019.

Further reading

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