Spla/ryanodine receptor domain and socs box containing 3

SplA/ryanodine receptor domain and SOCS box containing 3 is a protein that in humans is encoded by the SPSB3 gene.[5]

SPRY domain
Identifiers
Symbol	SPRY
Pfam	PF00622
InterPro	IPR003877
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

SPSB3
Identifiers
Aliases	SPSB3, C16orf31, SSB3, Spla/ryanodine receptor domain and socs box containing 3
External IDs	OMIM: 611659 MGI: 1891471 HomoloGene: 12322 GeneCards: SPSB3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 1,776,712 bp[1] End 1,793,700 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 24,886,643 bp[2] End 24,892,152 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • ubiquitin-protein transferase activity Cellular component • cytosol • SCF ubiquitin ligase complex Biological process • protein ubiquitination • post-translational modification • ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90864	79043
Ensembl	ENSG00000162032	ENSMUSG00000024160
UniProt	Q6PJ21	Q571F5
RefSeq (mRNA)	NM_080861 NM_001324081	NM_001163750 NM_001163751 NM_027141 NM_001374602
RefSeq (protein)	NP_001311010 NP_543137	NP_001157222 NP_001157223 NP_081417 NP_001361531
Location (UCSC)	Chr 16: 1.78 – 1.79 Mb	Chr 17: 24.89 – 24.89 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000162032 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024160 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SplA/ryanodine receptor domain and SOCS box containing 3".

External links

• Eukaryotic Linear Motif resource motif class LIG_SPRY_1

Further reading

• Nishiya T, Matsumoto K, Maekawa S, Kajita E, Horinouchi T, Fujimuro M, Ogasawara K, Uehara T, Miwa S (March 2011). "Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins". The Journal of Biological Chemistry. 286 (11): 9009–19. doi:10.1074/jbc.M110.190678. PMC 3058989. PMID 21199876.
• Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical Sciences. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Wang D, Li Z, Messing EM, Wu G (April 2005). "The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway". The Journal of Biological Chemistry. 280 (16): 16393–401. doi:10.1074/jbc.M413897200. PMID 15713673.
• Naukkarinen J, Surakka I, Pietiläinen KH, Rissanen A, Salomaa V, Ripatti S, Yki-Järvinen H, van Duijn CM, Wichmann HE, Kaprio J, Taskinen MR, Peltonen L (June 2010). Gibson G (ed.). "Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes". PLoS Genetics. 6 (6): e1000976. doi:10.1371/journal.pgen.1000976. PMC 2880558. PMID 20532202.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (February 2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Human Molecular Genetics. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.