Sh3 and sylf domain containing 1

SH3 and SYLF domain containing 1 is a protein that in humans is encoded by the SH3YL1 gene.[5]

SH3YL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8H
Identifiers
Aliases	SH3YL1, RAY, SH3 and SYLF domain containing 1
External IDs	OMIM: 617314 MGI: 1346118 HomoloGene: 31662 GeneCards: SH3YL1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p25.3 Start 217,730 bp[1] End 266,398 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A2 Start 30,911,668 bp[2] End 30,960,162 bp[2]
Gene ontology Molecular function • phosphatase binding • GO:0001948 protein binding • phosphatidylinositol binding Cellular component • ruffle membrane Biological process • phosphatidylinositol biosynthetic process • regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26751	24057
Ensembl	ENSG00000035115	ENSMUSG00000020669
UniProt	Q96HL8	O08641
RefSeq (mRNA)	NM_001159597 NM_001282682 NM_001282687 NM_015677	NM_001289480 NM_013709
RefSeq (protein)	NP_001153069 NP_001269611 NP_001269616 NP_056492	NP_001276409 NP_038737
Location (UCSC)	Chr 2: 0.22 – 0.27 Mb	Chr 12: 30.91 – 30.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000035115 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020669 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SH3 and SYLF domain containing 1".

Further reading

• Asbach B, Ludwig C, Saksela K, Wagner R (2012). "Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome". PLoS One. 7 (6): e38540. doi:10.1371/journal.pone.0038540. PMC 3379994. PMID 22745667.
• Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T (May 2011). "SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain". The Journal of Cell Biology. 193 (5): 901–16. doi:10.1083/jcb.201012161. PMC 3105542. PMID 21624956.
• Aoki N, Ito K, Ito M (May 2000). "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle". The Journal of Investigative Dermatology. 114 (5): 1050–6. doi:10.1046/j.1523-1747.2000.00971.x. PMID 10771491.
• Shimomura Y, Aoki N, Ito K, Ito M (February 2003). "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles". Journal of Dermatological Science. 31 (1): 43–51. doi:10.1016/s0923-1811(02)00140-8. PMID 12615363.