ST7

Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene.[5][6][7] ST7 orthologs [8] have been identified in all mammals for which complete genome data are available.

ST7
Identifiers
AliasesST7, ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7, suppression of tumorigenicity 7
External IDsOMIM: 600833 MGI: 1927450 HomoloGene: 10185 GeneCards: ST7
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q31.2Start116,953,238 bp[1]
End117,230,103 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

7982

64213

Ensembl

ENSG00000004866

ENSMUSG00000029534

UniProt

Q9NRC1

Q99M96

RefSeq (mRNA)

NM_021908
NM_018412

RefSeq (protein)
Location (UCSC)Chr 7: 116.95 – 117.23 MbChr 6: 17.69 – 17.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[7]

Interactions

ST7 has been shown to interact with ITGB1BP3[9] and GNB2L1.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000004866 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029534 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (October 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Molecular and Cellular Biology. 13 (10): 6036–43. doi:10.1128/mcb.13.10.6036. PMC 364663. PMID 8105370.
  6. Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (November 1996). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Research. 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430.
  7. "Entrez Gene: ST7 suppression of tumorigenicity 7".
  8. "OrthoMaM phylogenetic marker: ST7 coding sequence".
  9. Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.

Further reading

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