SMG5

Protein SMG5 is a protein that in humans is encoded by the SMG5 gene.[5][6][7] This protein contains a PIN domain that appears to have mutated the residues in the active site.[8]

SMG5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSMG5, EST1B, LPTS-RP1, LPTSRP1, SMG-5, nonsense mediated mRNA decay factor, SMG5 nonsense mediated mRNA decay factor
External IDsOMIM: 610962 MGI: 2447364 HomoloGene: 9095 GeneCards: SMG5
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q22Start156,249,224 bp[1]
End156,282,825 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23381

229512

Ensembl

ENSG00000198952

ENSMUSG00000001415

UniProt

Q9UPR3

Q6ZPY2

RefSeq (mRNA)

NM_015327
NM_001323614
NM_001323615
NM_001323616
NM_001323617

NM_173188
NM_178246

RefSeq (protein)

NP_001310543
NP_001310544
NP_001310545
NP_001310546
NP_056142

NP_839977

Location (UCSC)Chr 1: 156.25 – 156.28 MbChr 3: 88.34 – 88.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


References

  1. GRCh38: Ensembl release 89: ENSG00000198952 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001415 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reichenbach P, Hoss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (Apr 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Curr Biol. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087.
  6. Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (Apr 2003). "Functional conservation of the telomerase protein Est1p in humans". Curr Biol. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629.
  7. "Entrez Gene: SMG5 Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)".
  8. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006). "Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex". EMBO J. 25 (21): 5117–25. doi:10.1038/sj.emboj.7601377. PMC 1630413. PMID 17053788.

Further reading


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