SME
Economics
- Small and medium-sized enterprises
- Socialist market economy, an economic system of China
Organizations
Music
- SME Limited, UK audio turntable manufacturer
- Sony Music Entertainment, US
- Spontaneous Music Ensemble, UK, mid-1960s
Other organizations
- SME (society), formerly Society of Manufacturing Engineers
- Society for Mining, Metallurgy, and Exploration
- Sun Microelectronics, a business unit of Sun Microsystems
Science and technology
Computing
- Secure Memory Encryption, an AMD technology
- Structure mapping engine, in artificial intelligence and cognitive science
- SIGNAL Meta under Eclipse, in the SIGNAL programming language
Other uses in science and technology
- Standard-Model Extension, in quantum field theory
- Subsequent memory effect, in cognitive psychology
- Surface-mount equipment, for electronic assembly
- Solar Mesosphere Explorer, an Earth observation satellite
Other uses
- SME (newspaper), a Slovak daily
- Subject-matter expert, an authority in a particular area or topic
- Lake Cumberland Regional Airport IATA code
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