SERTAD1

SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.[5][6][7]

SERTAD1
Identifiers
Aliases	SERTAD1, SEI1, TRIP-Br1, SERTA domain containing 1, TRIPBR1
External IDs	OMIM: 617850 MGI: 1913438 HomoloGene: 8365 GeneCards: SERTAD1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 40,421,589 bp[1] End 40,425,992 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 27,486,910 bp[2] End 27,490,316 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cell nucleus Biological process • positive regulation of transcription, DNA-templated • positive regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of transcription, DNA-templated • negative regulation of cell growth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29950	55942
Ensembl	ENSG00000197019	ENSMUSG00000008384
UniProt	Q9UHV2 Q53GC0	Q9JL10
RefSeq (mRNA)	NM_013376	NM_018820
RefSeq (protein)	NP_037508 NP_037508.2	NP_061290
Location (UCSC)	Chr 19: 40.42 – 40.43 Mb	Chr 7: 27.49 – 27.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SERTAD1 has been shown to interact with:

• CREB-binding protein,[8]
• Cyclin-dependent kinase 4,[6][9] and
• P16.[6][9]

References

1. GRCh38: Ensembl release 89: ENSG00000197019 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008384 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Besley GT, Broadhead DM, Lawlor E (Nov 1984). "Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms". J Inherit Metab Dis. 7 Suppl 2: 155–6. doi:10.1007/978-94-009-5612-4_52. ISBN 978-94-010-8975-3. PMID 6434876.
6. Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Jan 2000). "Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1". Genes Dev. 13 (22): 3027–33. doi:10.1101/gad.13.22.3027. PMC 317153. PMID 10580009.
7. "Entrez Gene: SERTAD1 SERTA domain containing 1".
8. Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (Jun 2003). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
9. Li J, Melvin WS, Tsai MD, Muscarella P (Apr 2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry. 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.
• Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (2004). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
• Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM, Guan Sim K, Hsu SI, Bernard HU (2004). "The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1". Virology. 317 (1): 155–64. doi:10.1016/j.virol.2003.08.008. PMID 14675634.
• Li J, Melvin WS, Tsai MD, Muscarella P (2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry. 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.
• Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD (2006). "Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)". Biochemistry. 44 (40): 13246–56. doi:10.1021/bi0504658. PMID 16201750.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.