SEPT1

Septin-1 is a protein that in humans is encoded by the SEPT1 gene.[5][6]

SEPTIN1
Identifiers
Aliases	SEPTIN1, DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDs	OMIM: 612897 MGI: 1858916 HomoloGene: 23009 GeneCards: SEPTIN1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 30,378,133 bp[1] End 30,395,991 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F3 Start 127,214,447 bp[2] End 127,233,130 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • identical protein binding • GTPase activity • GO:0032947 molecular adaptor activity Cellular component • cytoplasm • cytoskeleton • microtubule organizing center • midbody • septin ring • synaptic vesicle • microtubule cytoskeleton • septin complex • septin filament array Biological process • cell division • cell cycle • mitotic cytokinesis • septin ring assembly • regulation of exocytosis • cilium morphogenesis • cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1731	54204
Ensembl	ENSG00000180096	ENSMUSG00000000486
UniProt	Q8WYJ6	P42209
RefSeq (mRNA)	NM_052838 NM_001365977	NM_017461
RefSeq (protein)	NP_443070 NP_001352906	NP_059489
Location (UCSC)	Chr 16: 30.38 – 30.4 Mb	Chr 7: 127.21 – 127.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000180096 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000486 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
6. "Entrez Gene: SEPT1 septin 1".

Further reading

• Nottenburg C, Gallatin WM, St John T (November 1990). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences". Gene. 95 (2): 279–84. doi:10.1016/0378-1119(90)90372-X. PMID 2174398.
• Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (November 1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease". The American Journal of Pathology. 153 (5): 1551–60. doi:10.1016/S0002-9440(10)65743-4. PMC 1853406. PMID 9811347.
• Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
• Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L (October 2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 (3): 994–1000. doi:10.1016/j.bbrc.2005.06.212. PMID 16179162.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (November 2007). "Overexpression of Septin1: possible contribution to the development of oral cancer". International Journal of Oncology. 31 (5): 1021–8. doi:10.3892/ijo.31.5.1021. PMID 17912427.