SEMA5A

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[5][6][7]

SEMA5A
Identifiers
AliasesSEMA5A, SEMAF, semF, semaphorin 5A
External IDsOMIM: 609297 MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p15.31Start9,035,033 bp[1]
End9,546,075 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9037

20356

Ensembl

ENSG00000112902

ENSMUSG00000022231

UniProt

Q13591

Q62217
Q3UPZ0

RefSeq (mRNA)

NM_003966

NM_009154

RefSeq (protein)

NP_003957

NP_033180

Location (UCSC)Chr 5: 9.04 – 9.55 MbChr 15: 32.24 – 32.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][7]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

References

  1. GRCh38: Ensembl release 89: ENSG00000112902 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022231 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
  6. Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
  7. "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading


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