SECTM1

Secreted and transmembrane protein 1 is a protein that in humans is encoded by the SECTM1 gene.[5][6]

SECTM1
Identifiers
Aliases	SECTM1, K12, secreted and transmembrane 1, SECTM
External IDs	OMIM: 602602 MGI: 2384805 HomoloGene: 134112 GeneCards: SECTM1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 82,321,024 bp[1] End 82,334,074 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 121,067,407 bp[2] End 121,081,220 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • cytokine activity Cellular component • extracellular region • Golgi apparatus • cell membrane • membrane • extracellular exosome • integral component of membrane • extracellular Biological process • mesoderm development • positive regulation of I-kappaB kinase/NF-kappaB signaling • immune response • signal transduction • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6398	209588
Ensembl	ENSG00000141574	ENSMUSG00000025165
UniProt	Q8WVN6	Q921W8
RefSeq (mRNA)	NM_003004	NM_145373
RefSeq (protein)	NP_002995	n/a
Location (UCSC)	Chr 17: 82.32 – 82.33 Mb	Chr 11: 121.07 – 121.08 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000141574 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025165 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Slentz-Kesler KA, Hale LP, Kaufman RE (Apr 1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms". Genomics. 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID 9480746.
6. "Entrez Gene: SECTM1 secreted and transmembrane 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lyman SD, Escobar S, Rousseau AM, et al. (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein". J. Biol. Chem. 275 (5): 3431–7. doi:10.1074/jbc.275.5.3431. PMID 10652336.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.