SAV1

Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene.[5][6][7]

SAV1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSAV1, SAV, WW45, WWP4, salvador family WW domain containing protein 1
External IDsOMIM: 607203 MGI: 1927144 HomoloGene: 32517 GeneCards: SAV1
Gene location (Human)
Chr.Chromosome 14 (human)[1]
Band14q22.1Start50,632,058 bp[1]
End50,668,306 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

60485

64010

Ensembl

ENSG00000151748

ENSMUSG00000021067

UniProt

Q9H4B6

Q8VEB2

RefSeq (mRNA)

NM_021818

NM_022028

RefSeq (protein)

NP_068590

NP_071311

Location (UCSC)Chr 14: 50.63 – 50.67 MbChr 12: 69.97 – 69.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000151748 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021067 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK (Aug 2002). "salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines". Cell. 110 (4): 467–78. doi:10.1016/S0092-8674(02)00824-3. PMID 12202036.
  6. Valverde P (Oct 2000). "Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene". Biochem Biophys Res Commun. 276 (3): 990–8. doi:10.1006/bbrc.2000.3582. PMID 11027580.
  7. "Entrez Gene: SAV1 salvador homolog 1 (Drosophila)".

Further reading


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