SARNP

SAP domain-containing ribonucleoprotein is a protein that in humans is encoded by the SARNP gene.[5][6][7]

SARNP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DO1
Identifiers
Aliases	SARNP, CIP29, HCC1, HSPC316, THO1, SAP domain containing ribonucleoprotein
External IDs	OMIM: 610049 MGI: 1913368 HomoloGene: 41628 GeneCards: SARNP
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 55,752,463 bp[1] End 55,817,724 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D3 Start 128,817,333 bp[2] End 128,877,629 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • RNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • protein C-terminus binding • RS domain binding Cellular component • nuclear speck • transcription export complex • cell nucleus • nucleoplasm • cytoplasmic ribonucleoprotein granule Biological process • mRNA transport • regulation of transcription, DNA-templated • regulation of translation • transcription, DNA-templated • RNA export from nucleus • mRNA export from nucleus • termination of RNA polymerase II transcription • mRNA 3'-end processing • transport • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84324	66118
Ensembl	ENSG00000205323	ENSMUSG00000078427
UniProt	P82979	Q9D1J3
RefSeq (mRNA)	NM_033082	NM_025364
RefSeq (protein)	NP_149073	NP_079640 NP_001346332 NP_001346333 NP_001346334 NP_001346335 NP_001346336
Location (UCSC)	Chr 12: 55.75 – 55.82 Mb	Chr 10: 128.82 – 128.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000205323 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078427 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Choong ML, Tan LK, Lo SL, Ren EC, Ou K, Ong SE, Liang RC, Seow TK, Chung MC (May 2001). "An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors". FEBS Lett. 496 (2–3): 109–16. doi:10.1016/S0014-5793(01)02409-7. PMID 11356193.
6. Fukuda S, Wu DW, Stark K, Pelus LM (Mar 2002). "Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29". Biochem Biophys Res Commun. 292 (3): 593–600. doi:10.1006/bbrc.2002.6680. PMID 11922608.
7. "Entrez Gene: CIP29 cytokine induced protein 29 kDa".

External links

• Human SARNP genome location and SARNP gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Navakauskiene R, Treigyte G, Gineitis A, Magnusson KE (2004). "Identification of apoptotic tyrosine-phosphorylated proteins after etoposide or retinoic acid treatment". Proteomics. 4 (4): 1029–41. doi:10.1002/pmic.200300671. PMID 15048984.
• Hashii Y, Kim JY, Sawada A, et al. (2004). "A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia". Leukemia. 18 (9): 1546–8. doi:10.1038/sj.leu.2403450. PMID 15284855.
• Leaw CL, Ren EC, Choong ML (2004). "Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function". Cell. Mol. Life Sci. 61 (17): 2264–73. doi:10.1007/s00018-004-4205-x. PMID 15338056.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sugiura T, Sakurai K, Nagano Y (2007). "Intracellular characterization of DDX39, a novel growth-associated RNA helicase". Exp. Cell Res. 313 (4): 782–90. doi:10.1016/j.yexcr.2006.11.014. PMID 17196963.