SAFB2

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.[5][6]

SAFB2
Identifiers
Aliases	SAFB2, scaffold attachment factor B2
External IDs	OMIM: 608066 MGI: 2146808 HomoloGene: 35210 GeneCards: SAFB2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 5,586,999 bp[1] End 5,624,046 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 56,560,965 bp[2] End 56,584,585 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • nucleic acid binding • identical protein binding • GO:0001948 protein binding • double-stranded DNA binding • RNA binding • sequence-specific DNA binding Cellular component • extracellular exosome • nucleoplasm • cytoplasm • intracellular membrane-bounded organelle • cell nucleus • nuclear body Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • Sertoli cell differentiation • regulation of transcription from RNA polymerase II promoter • regulation of androgen receptor signaling pathway • regulation of mRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9667	224902
Ensembl	ENSG00000130254	ENSMUSG00000042625
UniProt	Q14151	Q80YR5
RefSeq (mRNA)	NM_014649	NM_001029979 NM_001355463
RefSeq (protein)	NP_055464	NP_001025150 NP_001342392
Location (UCSC)	Chr 19: 5.59 – 5.62 Mb	Chr 17: 56.56 – 56.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha[5] and SAFB.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000130254 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042625 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
6. "Entrez Gene: SAFB2 scaffold attachment factor B2".

Further reading

• Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024.
• Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.