RRP1B

RRP1B (ribosomal RNA processing 1 homolog B), also known as KIAA0179, is a human gene[5] which is located on Chromosome 21.

RRP1B
Identifiers
Aliases	RRP1B, KIAA0179, NNP1L, Nnp1, PPP1R136, RRP1, ribosomal RNA processing 1B
External IDs	OMIM: 610654 MGI: 1919712 HomoloGene: 57086 GeneCards: RRP1B
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 43,659,560 bp[1] End 43,696,079 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 32,036,100 bp[2] End 32,062,865 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA binding • GO:0001105 transcription coactivator activity • GO:0001948 protein binding Cellular component • heterochromatin • preribosome, small subunit precursor • cytosol • euchromatin • nucleolus • cell nucleus • preribosome, large subunit precursor • granular component • nucleoplasm • chromosome Biological process • negative regulation of phosphatase activity • rRNA processing • GO:0034259 negative regulation of GTPase activity • positive regulation of apoptotic process • regulation of RNA splicing • positive regulation of transcription from RNA polymerase II promoter • cellular response to virus • mRNA processing • apoptotic process • RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23076	72462
Ensembl	ENSG00000160208	ENSMUSG00000058392
UniProt	Q14684	Q91YK2
RefSeq (mRNA)	NM_015056	NM_001163734 NM_028244
RefSeq (protein)	NP_055871	NP_001157206 NP_082520
Location (UCSC)	Chr 21: 43.66 – 43.7 Mb	Chr 17: 32.04 – 32.06 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000160208 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058392 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KIAA0179 KIAA0179".

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (June 2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.