RRAGA

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.[5][6][7]

RRAGA
Identifiers
Aliases	RRAGA, FIP-1, FIP1, RAGA, Ras related GTP binding A
External IDs	OMIM: 612194 MGI: 1915691 HomoloGene: 68522 GeneCards: RRAGA
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.1 Start 19,049,427 bp[1] End 19,051,025 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C4 Start 86,575,668 bp[2] End 86,577,285 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • nucleotide binding • protein homodimerization activity • GTP binding • phosphoprotein binding • GO:0001948 protein binding • GTPase activity • ubiquitin protein ligase binding • protein heterodimerization activity Cellular component • cytoplasm • cytosol • GATOR1 complex • lysosomal membrane • lysosome • cell nucleus • EGO complex • Gtr1-Gtr2 GTPase complex Biological process • cellular response to amino acid starvation • cell death • positive regulation of cytolysis • positive regulation of TORC1 signaling • cellular protein localization • modulation by virus of host morphology or physiology • cell cycle arrest • cellular response to amino acid stimulus • GO:0022415 viral process • negative regulation of autophagy • positive regulation of TOR signaling • apoptotic process • protein ubiquitination • regulation of macroautophagy • cellular response to starvation • regulation of autophagy Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10670	68441
Ensembl	ENSG00000155876	ENSMUSG00000070934
UniProt	Q7L523	Q80X95
RefSeq (mRNA)	NM_006570	NM_178376
RefSeq (protein)	NP_006561	NP_848463
Location (UCSC)	Chr 9: 19.05 – 19.05 Mb	Chr 4: 86.58 – 86.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RRAGA has been shown to interact with NOL8[8] and RRAGC.[9][10]

References

1. GRCh38: Ensembl release 89: ENSG00000155876 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070934 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
6. Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. PMC 191215. PMID 8995684.
7. "Entrez Gene: RRAGA Ras-related GTP binding A".
8. Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
9. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
10. Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

Further reading

• Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Jan 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". Journal of Cell Science. 111 ( Pt 1) (1): 11–21. PMID 9394008.
• Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
• Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.