RNH1

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.[5]

RNH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z7X, 1A4Y, 2BEX, 2Q4G
Identifiers
Aliases	RNH1, RAI, RNH, ribonuclease/angiogenin inhibitor 1
External IDs	OMIM: 173320 MGI: 1195456 HomoloGene: 2204 GeneCards: RNH1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 494,512 bp[1] End 507,300 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,160,326 bp[2] End 141,172,857 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribonuclease inhibitor activity • GO:0001948 protein binding Cellular component • angiogenin-PRI complex • extracellular exosome • nucleoplasm • cytoplasm • cytosol Biological process • regulation of angiogenesis • mRNA catabolic process • GO:0048553 negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6050	107702
Ensembl	ENSG00000276230 ENSG00000023191	ENSMUSG00000038650
UniProt	P13489	Q91VI7
RefSeq (mRNA)	NM_002939 NM_203383 NM_203384 NM_203385 NM_203386 NM_203387 NM_203388 NM_203389	NM_001172100 NM_001172101 NM_145135
RefSeq (protein)	NP_002930 NP_976317 NP_976318 NP_976319 NP_976320 NP_976321 NP_976322 NP_976323	NP_001165571 NP_001165572 NP_660117
Location (UCSC)	Chr 11: 0.49 – 0.51 Mb	Chr 7: 141.16 – 141.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000023191 GRCh38: Ensembl release 89: ENSG00000276230, ENSG00000023191 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038650 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1".

Further reading

• Zneimer SM, Crawford D, Schneider NR, Beutler B (1991). "Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization". Genomics. 8 (1): 175–8. doi:10.1016/0888-7543(90)90242-M. PMID 2081593.
• Weremowicz S, Fox EA, Morton CC, Vallee BL (1991). "The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5". Genomics. 8 (4): 717–21. doi:10.1016/0888-7543(90)90260-2. PMID 2276743.
• Lee FS, Vallee BL (1989). "Binding of placental ribonuclease inhibitor to the active site of angiogenin". Biochemistry. 28 (8): 3556–61. doi:10.1021/bi00434a061. PMID 2742853.
• Bond MD, Vallee BL (1989). "Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay". Biochemistry. 27 (17): 6282–7. doi:10.1021/bi00417a013. PMID 3064806.
• Hofsteenge J, Kieffer B, Matthies R, et al. (1989). "Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats". Biochemistry. 27 (23): 8537–44. doi:10.1021/bi00423a006. PMID 3219361.
• Lee FS, Fox EA, Zhou HM, et al. (1989). "Primary structure of human placental ribonuclease inhibitor". Biochemistry. 27 (23): 8545–53. doi:10.1021/bi00423a007. PMID 3219362.
• Schneider R, Schneider-Scherzer E, Thurnher M, et al. (1989). "The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module". EMBO J. 7 (13): 4151–6. PMC 455125. PMID 3243277.
• Shapiro R, Vallee BL (1987). "Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin". Proc. Natl. Acad. Sci. U.S.A. 84 (8): 2238–41. doi:10.1073/pnas.84.8.2238. PMC 304624. PMID 3470787.
• Kiyohara H, Menjo M (1984). "Ribonuclease and ribonuclease inhibitor in the human pancreas". Gastroenterol. Jpn. 18 (5): 468–73. PMID 6653993.
• Nadano D, Yasuda T, Takeshita H, et al. (1994). "Purification and characterization of human brain ribonuclease inhibitor". Arch. Biochem. Biophys. 312 (2): 421–8. doi:10.1006/abbi.1994.1328. PMID 8037455.
• Kobe B, Deisenhofer J (1994). "Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats". Nature. 366 (6457): 751–6. doi:10.1038/366751a0. PMID 8264799.
• Papageorgiou AC, Shapiro R, Acharya KR (1997). "Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution". EMBO J. 16 (17): 5162–77. doi:10.1093/emboj/16.17.5162. PMC 1170149. PMID 9311977.
• Gaur D, Swaminathan S, Batra JK (2001). "Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants". J. Biol. Chem. 276 (27): 24978–84. doi:10.1074/jbc.M102440200. PMID 11342552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fu P, Chen J, Tian Y, et al. (2005). "Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor". Cancer Gene Ther. 12 (3): 268–75. doi:10.1038/sj.cgt.7700742. PMID 15592448.
• Iyer S, Holloway DE, Kumar K, et al. (2005). "Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor". J. Mol. Biol. 347 (3): 637–55. doi:10.1016/j.jmb.2005.01.035. PMID 15755456.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Johnson RJ, McCoy JG, Bingman CA, et al. (2007). "Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein". J. Mol. Biol. 368 (2): 434–49. doi:10.1016/j.jmb.2007.02.005. PMC 1993901. PMID 17350650.