RNF12

E3 ubiquitin-protein ligase RLIM is an enzyme that in humans is encoded by the RLIM gene.[5][6]

RLIM
Identifiers
AliasesRLIM, NY-REN-43, RNF12, ring finger protein, LIM domain interacting, MRX61, TOKAS
External IDsOMIM: 300379 MGI: 1342291 HomoloGene: 7920 GeneCards: RLIM
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq13.2Start74,582,976 bp[1]
End74,614,624 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51132

19820

Ensembl

ENSG00000131263

ENSMUSG00000056537

UniProt

Q9NVW2

Q9WTV7

RefSeq (mRNA)

NM_183353
NM_016120

NM_011276
NM_001358205

RefSeq (protein)

NP_057204
NP_899196

NP_035406
NP_001345134

Location (UCSC)Chr X: 74.58 – 74.61 MbChr X: 103.96 – 103.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be a ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Alternatively spliced transcript variants encoding the same protein have been reported.[6] Functions in female mice as a regulator of X chromosome inactivation .

Interactions

RNF12 has been shown to interact with Estrogen receptor alpha.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000131263 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056537 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  6. "Entrez Gene: RNF12 ring finger protein 12".
  7. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I (Jan 2009). "Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer". Cancer Res. 69 (1): 128–36. doi:10.1158/0008-5472.CAN-08-1630. PMC 2713826. PMID 19117995.

Further reading


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