RIC3

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.[5] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors,[6][7] particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.[8]

RIC3
Identifiers
AliasesRIC3, AYST720, PRO1385, RIC3 acetylcholine receptor chaperone
External IDsOMIM: 610509 MGI: 2443887 HomoloGene: 49772 GeneCards: RIC3
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start8,106,056 bp[1]
End8,169,055 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79608

320360

Ensembl

ENSG00000166405

ENSMUSG00000048330

UniProt

Q7Z5B4

Q8BPM6

RefSeq (mRNA)

NM_001038624
NM_178780
NM_001311161

RefSeq (protein)

NP_001033713
NP_001298090
NP_848895

Location (UCSC)Chr 11: 8.11 – 8.17 MbChr 7: 109.03 – 109.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000166405 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000048330 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics. 140 (2): 527–35. PMC 1206632. PMID 7498734.
  6. Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem. 278 (36): 34411–7. doi:10.1074/jbc.M300170200. PMID 12821669.
  7. "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)".
  8. Williams ME, Burton B, Urrutia A, et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725.

Further reading


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