RHOJ

Rho-related GTP-binding protein RhoJ is a protein that in humans is encoded by the RHOJ gene.[5][6]

RHOJ
Identifiers
Aliases	RHOJ, ARHJ, RASL7B, TC10B, TCL, ras homolog family member J
External IDs	OMIM: 607653 MGI: 1931551 HomoloGene: 56894 GeneCards: RHOJ
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.2 Start 63,204,114 bp[1] End 63,293,508 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 75,308,322 bp[2] End 75,401,456 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • GTPase activity • protein kinase binding Cellular component • cytosol • cell membrane • extracellular exosome • membrane • intracellular • cytoplasm • cell cortex • cell projection Biological process • regulation of small GTPase mediated signal transduction • retina vasculature morphogenesis in camera-type eye • actin cytoskeleton organization • Rho protein signal transduction • regulation of cell shape • small GTPase mediated signal transduction • angiogenesis • endocytosis • actin filament organization • establishment or maintenance of cell polarity • regulation of endothelial cell migration • cell projection assembly • regulation of actin cytoskeleton organization • positive regulation of cell migration involved in sprouting angiogenesis • regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57381	80837
Ensembl	ENSG00000126785	ENSMUSG00000046768
UniProt	Q9H4E5	Q9ER71
RefSeq (mRNA)	NM_020663	NM_023275
RefSeq (protein)	NP_065714 NP_065714.1	NP_075764
Location (UCSC)	Chr 14: 63.2 – 63.29 Mb	Chr 12: 75.31 – 75.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ARHJ belongs to the Rho family of small GTP-binding proteins. Rho proteins regulate the dynamic assembly of cytoskeletal components for several physiologic processes, such as cell proliferation and motility and the establishment of cell polarity. They are also involved in pathophysiologic process, such as cell transformation and metastasis.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000126785 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046768 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouviere C, Blangy A, Fort P (Dec 2000). "Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42". J Biol Chem. 275 (46): 36457–64. doi:10.1074/jbc.M003487200. PMID 10967094.
6. "Entrez Gene: RHOJ ras homolog gene family, member J".

Further reading

• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Nishikimi A, Meller N, Uekawa N, et al. (2005). "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes". FEBS Lett. 579 (5): 1039–46. doi:10.1016/j.febslet.2005.01.006. PMID 15710388.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ruusala A, Aspenström P (2004). "Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology". FEBS Lett. 572 (1–3): 159–66. doi:10.1016/j.febslet.2004.06.095. PMID 15304341.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• de Toledo M, Senic-Matuglia F, Salamero J, et al. (2004). "The GTP/GDP Cycling of Rho GTPase TCL Is an Essential Regulator of the Early Endocytic Pathway". Mol. Biol. Cell. 14 (12): 4846–56. doi:10.1091/mbc.E03-04-0254. PMC 284789. PMID 12960428.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.