RCBTB2

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.[5][6]

RCBTB2
Identifiers
Aliases	RCBTB2, CHC1L, RLG, RCC1 and BTB domain containing protein 2
External IDs	OMIM: 603524 MGI: 1917200 HomoloGene: 970 GeneCards: RCBTB2
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.2 Start 48,488,959 bp[1] End 48,533,256 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 73,123,037 bp[2] End 73,207,843 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Ran guanyl-nucleotide exchange factor activity • GO:0001948 protein binding Cellular component • Acrosome • cytoplasmic vesicle Biological process • regulation of molecular function Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1102	105670
Ensembl	ENSG00000136161	ENSMUSG00000022106
UniProt	O95199	Q99LJ7
RefSeq (mRNA)	NM_001268 NM_001286830 NM_001286831 NM_001286832 NM_001352424 NM_001352425 NM_001352426 NM_001352427 NM_001352428 NM_001352429 NM_001352430 NM_001352431	NM_001170694 NM_134083
RefSeq (protein)	NP_001259 NP_001273759 NP_001273760 NP_001273761 NP_001339353 NP_001339354 NP_001339355 NP_001339356 NP_001339357 NP_001339358 NP_001339359 NP_001339360	NP_001164165 NP_598844
Location (UCSC)	Chr 13: 48.49 – 48.53 Mb	Chr 14: 73.12 – 73.21 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000136161 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022106 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.
6. "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Latil A, Morant P, Fournier G, et al. (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer. 99 (5): 689–96. doi:10.1002/ijc.10393. PMID 12115502.
• Renault L, Nassar N, Wittinghofer A, et al. (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.