RBM39

RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[5][6]

RBM39
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBM39, CAPER, CAPERalpha, FSAP59, HCC1, RNPC2, RNA binding motif protein 39
External IDsOMIM: 604739 MGI: 2157953 HomoloGene: 136465 GeneCards: RBM39
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.22Start35,701,347 bp[1]
End35,742,312 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9584

170791

Ensembl

ENSG00000131051

ENSMUSG00000027620

UniProt

Q14498
Q5QP23

Q8VH51

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 20: 35.7 – 35.74 MbChr 2: 156.15 – 156.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[6]

Interactions

RBM39 has been shown to interact with Estrogen receptor alpha,[7] Estrogen receptor beta[7] and C-jun.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000131051 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027620 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma". J Clin Invest. 92 (5): 2419–26. doi:10.1172/JCI116848. PMC 288425. PMID 8227358.
  6. "Entrez Gene: RBM39 RNA binding motif protein 39".
  7. Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). "Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors". J. Biol. Chem. 277 (2): 1229–34. doi:10.1074/jbc.M110417200. PMID 11704680.

Further reading


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