RABIF

Guanine nucleotide exchange factor MSS4 is a protein that in humans is encoded by the RABIF gene.[4][5][6]

RABIF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FWQ, 2FU5
Identifiers
Aliases	RABIF, MSS4, RASGFR3, RASGRF3, RAB interacting factor
External IDs	OMIM: 603417 MGI: 2138605 HomoloGene: 37702 GeneCards: RABIF
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 202,878,282 bp[1] End 202,889,149 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • zinc ion binding • GO:0001948 protein binding • metal ion binding • guanyl-nucleotide exchange factor activity Cellular component • cytosol • membrane Biological process • protein transport • small GTPase mediated signal transduction • Lipid bilayer fusion • post-Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5877	98710
Ensembl	ENSG00000183155	n/a
UniProt	P47224	Q91X96
RefSeq (mRNA)	NM_002871	NM_145510
RefSeq (protein)	NP_002862	NP_663485
Location (UCSC)	Chr 1: 202.88 – 202.89 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000183155 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Müller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Büchler M, Adler G, Gress TM (Mar 1998). "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer". Genomics. 46 (3): 389–96. doi:10.1006/geno.1997.5049. PMID 9441742.
5. Yu H, Schreiber SL (Aug 1995). "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4". Biochemistry. 34 (28): 9103–10. CiteSeerX 10.1.1.540.2153. doi:10.1021/bi00028a020. PMID 7619808.
6. "Entrez Gene: RABIF RAB interacting factor".

Further reading

• Yu H, Schreiber SL (1995). "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface". Nature. 376 (6543): 788–91. doi:10.1038/376788a0. PMID 7651540.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Burton JL, Slepnev V, De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4". J. Biol. Chem. 272 (6): 3663–8. doi:10.1074/jbc.272.6.3663. PMID 9013620.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2–3): 351–5. doi:10.1016/S0014-5793(99)00151-9. PMID 10094488.
• Strick DJ, Francescutti DM, Zhao Y, Elferink LA (2002). "Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis". J. Biol. Chem. 277 (36): 32722–9. doi:10.1074/jbc.M205101200. PMID 12105226.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.