RABGAP1

RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene.[5]

RABGAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NC6
Identifiers
Aliases	RABGAP1, GAPCENA, TBC1D11, RAB GTPase activating protein 1
External IDs	OMIM: 615882 MGI: 2385139 HomoloGene: 49301 GeneCards: RABGAP1
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q33.2-q33.3 Start 122,940,833 bp[1] End 123,104,866 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 37,443,279 bp[2] End 37,566,454 bp[2]
Gene ontology Molecular function • tubulin binding • Rab GTPase binding • GO:0001948 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component • cytoplasm • cytosol • centrosome • cytoskeleton • microtubule associated complex • microtubule organizing center • endomembrane system Biological process • regulation of cilium assembly • cell cycle • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • regulation of vesicle fusion • intracellular protein transport • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23637	227800
Ensembl	ENSG00000011454	ENSMUSG00000035437
UniProt	Q9Y3P9	A2AWA9
RefSeq (mRNA)	NM_012197	NM_001033960 NM_146121 NM_001362956 NM_001362957 NM_001362958
RefSeq (protein)	NP_036329	NP_001029132 NP_666233 NP_001349885 NP_001349886 NP_001349887
Location (UCSC)	Chr 9: 122.94 – 123.1 Mb	Chr 2: 37.44 – 37.57 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000011454 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035437 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RAB GTPase activating protein 1".

Further reading

• Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, Napolitano M, Russo T, Zambrano N (February 2007). "Identification of the ligands of protein interaction domains through a functional approach". Molecular & Cellular Proteomics. 6 (2): 333–45. doi:10.1074/mcp.M600289-MCP200. PMID 17124247.
• Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Molecular Biology of the Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
• Ishibashi K, Kanno E, Itoh T, Fukuda M (January 2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes to Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034.
• Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (August 2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". Journal of Cell Science. 113 ( Pt 15) (15): 2725–35. PMID 10893188.
• Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (April 1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC 1171263. PMID 10202141.