Putrescine N-methyltransferase

In enzymology, a putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + putrescine S-adenosyl-L-homocysteine + N-methylputrescine
putrescine N-methyltransferase
Identifiers
EC number2.1.1.53
CAS number9075-39-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and putrescine, whereas its two products are S-adenosylhomocysteine and N-methylputrescine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:putrescine N-methyltransferase. This enzyme is also called putrescine methyltransferase. This enzyme participates in alkaloid biosynthesis ii.

This enzyme is important in the synthesis of many plant alkaloids.[1] It evolved from spermidine synthase.[2]

References

  1. Biastoff S, Brandt W, Dräger B (2009-10-01). "Putrescine N-methyltransferase--the start for alkaloids". Phytochemistry. Evolution of Metabolic Diversity. 70 (15–16): 1708–18. doi:10.1016/j.phytochem.2009.06.012. PMID 19651420.
  2. Junker A, Fischer J, Sichhart Y, Brandt W, Dräger B (2013-01-01). "Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase". Frontiers in Plant Science. 4: 260. doi:10.3389/fpls.2013.00260. PMC 3725402. PMID 23908659.
  • Mizusaki S, Tanabe Y, Noguchi M, Tamaki E (1971). "Phytochemical studies on tobacco alkaloids. XIV. The occurrence and properties of putrescine N-methyltransferase in tobacco roots". Plant Cell Physiol. 12: 633–640.


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