PURB

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.[5][6]

PURB
Identifiers
Aliases	PURB, PURBETA, purine-rich element binding protein B, purine rich element binding protein B
External IDs	OMIM: 608887 MGI: 1338779 HomoloGene: 69087 GeneCards: PURB
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,876,299 bp[1] End 44,885,530 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.16 cM Start 6,467,599 bp[2] End 6,475,917 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • RNA polymerase II regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • DNA binding • double-stranded DNA binding • SMAD binding • single-stranded DNA binding • transcription factor binding • mRNA binding • RNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • purine-rich negative regulatory element binding • sequence-specific DNA binding Cellular component • DNA replication factor A complex • cell nucleus Biological process • regulation of myeloid cell differentiation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • cellular proliferation • cell differentiation • transcription, DNA-templated • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5814	19291
Ensembl	ENSG00000146676	ENSMUSG00000094483
UniProt	Q96QR8	O35295
RefSeq (mRNA)	NM_033224	NM_011221
RefSeq (protein)	NP_150093	NP_035351
Location (UCSC)	Chr 7: 44.88 – 44.89 Mb	Chr 11: 6.47 – 6.48 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans.

Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000146676 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000094483 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC 360507. PMID 1448097.
6. "Entrez Gene: PURB purine-rich element binding protein B".

Further reading

• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
• Lezon-Geyda K, Najfeld V, Johnson EM (2001). "Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia". Leukemia. 15 (6): 954–62. doi:10.1038/sj.leu.2402108. PMID 11417483.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Gupta M, Sueblinvong V, Raman J, et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.