PRUNE2

Protein prune homolog 2 is a protein that in humans is encoded by the PRUNE2 gene.[5][6]

PRUNE2
Identifiers
Aliases	PRUNE2, A214N16.3, BMCC1, BNIPXL, C9orf65, KIAA0367, bA214N16.3, prune homolog 2 (Drosophila), prune homolog 2, prune homolog 2 with BCH domain
External IDs	OMIM: 610691 MGI: 1925004 HomoloGene: 18939 GeneCards: PRUNE2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q21.2 Start 76,611,376 bp[1] End 76,906,114 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 B Start 16,956,118 bp[2] End 17,223,932 bp[2]
Gene ontology Molecular function • pyrophosphatase activity • metal ion binding • exopolyphosphatase activity Cellular component • cytoplasm Biological process • apoptotic process • polyphosphate catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	158471	353211
Ensembl	ENSG00000106772	ENSMUSG00000039126
UniProt	Q8WUY3	Q52KR3
RefSeq (mRNA)	NM_001308047 NM_001308048 NM_001308049 NM_001308050 NM_001308051 NM_015225 NM_138818 NM_001330680	NM_181348
RefSeq (protein)	NP_001294976 NP_001294977 NP_001294978 NP_001294979 NP_001294980 NP_001317609 NP_056040 NP_001294976.1 NP_001294977.1	NP_851993
Location (UCSC)	Chr 9: 76.61 – 76.91 Mb	Chr 19: 16.96 – 17.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000106772 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039126 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Machida T, Fujita T, Ooo ML, Ohira M, Isogai E, Mihara M, Hirato J, Tomotsune D, Hirata T, Fujimori M, Adachi W, Nakagawara A (Mar 2006). "Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas". Oncogene. 25 (13): 1931–42. doi:10.1038/sj.onc.1209225. PMID 16288218.
6. "Entrez Gene: PRUNE2 prune homolog 2 (Drosophila)".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Price ND, Trent J, El-Naggar AK, et al. (2007). "Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3414–9. doi:10.1073/pnas.0611373104. PMC 1805517. PMID 17360660.