PRSS16

Thymus-specific serine protease is an enzyme that in humans is encoded by the PRSS16 gene.[5][6]

PRSS16
Identifiers
Aliases	PRSS16, TSSP, protease, serine 16, serine protease 16
External IDs	OMIM: 607169 MGI: 1859181 HomoloGene: 38106 GeneCards: PRSS16
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,247,701 bp[1] End 27,256,624 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A3.1|13 8.12 cM Start 22,002,173 bp[2] End 22,009,742 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • hydrolase activity • dipeptidyl-peptidase activity Cellular component • endosome • lysosome • cytoplasmic vesicle Biological process • protein catabolic process • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10279	54373
Ensembl	ENSG00000112812	ENSMUSG00000006179
UniProt	Q9NQE7	Q9QXE5
RefSeq (mRNA)	NM_005865	NM_019429
RefSeq (protein)	NP_005856	NP_062302
Location (UCSC)	Chr 6: 27.25 – 27.26 Mb	Chr 13: 22 – 22.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells.

The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000112812 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006179 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bowlus CL, Ahn J, Chu T, Gruen JR (Nov 1999). "Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus". Cell Immunol. 196 (2): 80–6. doi:10.1006/cimm.1999.1543. PMID 10527559.
6. "Entrez Gene: PRSS16 protease, serine, 16 (thymus)".

Further reading

• Lie BA, Viken MK, Akselsen HE, et al. (2007). "Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease". Hum. Immunol. 68 (7): 592–8. doi:10.1016/j.humimm.2007.03.009. PMID 17584581.
• Luther C, Wienhold W, Oehlmann R, et al. (2005). "Alternatively spliced transcripts of the thymus-specific protease PRSS16 are differentially expressed in human thymus". Genes Immun. 6 (1): 1–7. doi:10.1038/sj.gene.6364142. PMID 15592422.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Lie BA, Akselsen HE, Bowlus CL, et al. (2003). "Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases". Genes Immun. 3 (5): 306–12. doi:10.1038/sj.gene.6363858. PMID 12140752.
• Gruen JR, Nalabolu SR, Chu TW, et al. (1997). "A transcription map of the major histocompatibility complex (MHC) class I region". Genomics. 36 (1): 70–85. doi:10.1006/geno.1996.0427. PMID 8812418.

External links

• PRSS16 human gene location in the UCSC Genome Browser.
• PRSS16 human gene details in the UCSC Genome Browser.