PREX2

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.[5][6]

PREX2
Identifiers
Aliases	PREX2, 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
External IDs	OMIM: 612139 MGI: 1923385 HomoloGene: 23523 GeneCards: PREX2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.2 Start 67,952,046 bp[1] End 68,237,032 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A2 Start 10,993,465 bp[2] End 11,303,681 bp[2]
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • guanyl-nucleotide exchange factor activity • Rac guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • cell membrane • cytosol Biological process • adult locomotory behavior • phosphatidylinositol 3-kinase signaling • G-protein coupled receptor signaling pathway • regulation of Rho protein signal transduction • GO:0007243 intracellular signal transduction • dendrite morphogenesis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of protein kinase activity • negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80243	109294
Ensembl	ENSG00000046889	ENSMUSG00000048960
UniProt	Q70Z35	Q3LAC4
RefSeq (mRNA)	NM_024870 NM_025170	NM_001033636 NM_029525
RefSeq (protein)	NP_079146 NP_079446	NP_001028808 NP_083801
Location (UCSC)	Chr 8: 67.95 – 68.24 Mb	Chr 1: 10.99 – 11.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical relevance

Mutations in this gene have been recurrently seen in melanoma.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000046889 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048960 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2". Retrieved 2012-05-11.
6. Rosenfeldt H, Vázquez-Prado J, Gutkind JS (August 2004). "P-REX2, a novel PI-3-kinase sensitive Rac exchange factor". FEBS Lett. 572 (1–3): 167–71. doi:10.1016/j.febslet.2004.06.097. PMID 15304342.
7. Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA (May 2012). "Melanoma genome sequencing reveals frequent PREX2 mutations" (PDF). Nature. 485 (7399): 502–6. doi:10.1038/nature11071. PMC 3367798. PMID 22622578.

Further reading

• Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, Andrews SR, Walker SA, Hawkins PT, Stephens LR, Welch HC (August 2004). "P-Rex2, a new guanine-nucleotide exchange factor for Rac". FEBS Lett. 572 (1–3): 172–6. doi:10.1016/j.febslet.2004.06.096. PMID 15304343.
• Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J (August 2007). "P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration". J. Biol. Chem. 282 (32): 23708–15. doi:10.1074/jbc.M703771200. PMID 17565979.
• Joseph RE, Norris FA (July 2005). "Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2". J. Biol. Chem. 280 (30): 27508–12. doi:10.1074/jbc.M412495200. PMID 15897194.
• Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R (September 2009). "Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a". Science. 325 (5945): 1261–5. doi:10.1126/science.1173569. PMC 2936784. PMID 19729658.
• Leslie NR (2009). "P-REX2a driving tumorigenesis by PTEN inhibition". Sci Signal. 2 (94): pe68. doi:10.1126/scisignal.294pe68. PMID 19861688.