PPIL4

Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.[5]

PPIL4
Identifiers
Aliases	PPIL4, HDCME13P, peptidylprolyl isomerase like 4
External IDs	OMIM: 607609 MGI: 1914668 HomoloGene: 12126 GeneCards: PPIL4
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.1 Start 149,504,495 bp[1] End 149,546,043 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A1 Start 7,792,891 bp[2] End 7,823,135 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • isomerase activity • nucleic acid binding • RNA binding • peptidyl-prolyl cis-trans isomerase activity Cellular component • cell nucleus • nucleoplasm • cytosol Biological process • protein peptidyl-prolyl isomerization • regulation of phosphorylation of RNA polymerase II C-terminal domain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	85313	67418
Ensembl	ENSG00000131013	ENSMUSG00000015757
UniProt	Q8WUA2	Q9CXG3
RefSeq (mRNA)	NM_139126	NM_026141
RefSeq (protein)	NP_624311	NP_080417
Location (UCSC)	Chr 6: 149.5 – 149.55 Mb	Chr 10: 7.79 – 7.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000131013 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015757 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4".

Further reading

• Zeng L, Zhou Z, Xu J, et al. (2002). "Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain". Cytogenet. Cell Genet. 95 (1–2): 43–7. doi:10.1159/000057015. PMID 11978968.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.