PPIH

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.[5][6][7]

PPIH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MZW, 1QOI
Identifiers
Aliases	PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs	OMIM: 606095 MGI: 106499 HomoloGene: 38172 GeneCards: PPIH
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 42,658,423 bp[1] End 42,676,758 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.1|4 55.34 cM Start 119,300,010 bp[2] End 119,320,546 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribonucleoprotein complex binding • isomerase activity • GO:0001948 protein binding • peptidyl-prolyl cis-trans isomerase activity • cyclosporin A binding • unfolded protein binding Cellular component • cytoplasm • nuclear speck • U4/U6 x U5 tri-snRNP complex • spliceosomal complex • cell nucleus • nucleoplasm • U4/U6 snRNP Biological process • mRNA splicing, via spliceosome • mRNA processing • positive regulation of viral genome replication • protein folding • RNA splicing • macromolecular complex assembly • protein peptidyl-prolyl isomerization • angiogenesis • protein refolding Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10465	66101
Ensembl	ENSG00000171960	ENSMUSG00000060288
UniProt	O43447	Q9D868
RefSeq (mRNA)	NM_006347 NM_001330510	NM_001110129 NM_001110130 NM_028677
RefSeq (protein)	NP_001317439 NP_006338	NP_001103599 NP_001103600 NP_082953
Location (UCSC)	Chr 1: 42.66 – 42.68 Mb	Chr 4: 119.3 – 119.32 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171960 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
6. Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC 1369602. PMID 9570313.
7. "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

Further reading

• Reidt U, Reuter K, Achsel T, et al. (2000). "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin" (PDF). J. Biol. Chem. 275 (11): 7439–42. doi:10.1074/jbc.275.11.7439. PMID 10713041.
• Horowitz DS, Lee EJ, Mabon SA, Misteli T (2002). "A cyclophilin functions in pre-mRNA splicing". EMBO J. 21 (3): 470–80. doi:10.1093/emboj/21.3.470. PMC 125845. PMID 11823439.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide". J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. hdl:11858/00-001M-0000-0012-F238-B. PMID 12875835.
• Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein–protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC 169899. PMID 12907720.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.