POP5

Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene.[5][6]

POP5
Identifiers
Aliases	POP5, HSPC004, RPP2, RPP20, hPop5, POP5 homolog, ribonuclease P/MRP subunit
External IDs	OMIM: 609992 MGI: 2151221 HomoloGene: 41076 GeneCards: POP5
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 120,578,764 bp[1] End 120,581,402 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 115,235,836 bp[2] End 115,245,351 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ribonuclease activity • GO:0001948 protein binding • hydrolase activity • ribonuclease P activity Cellular component • nucleolus • nucleolar ribonuclease P complex • cell nucleus • nucleoplasm • ribonuclease MRP complex • multimeric ribonuclease P complex Biological process • RNA metabolic process • RNA phosphodiester bond hydrolysis • RNA phosphodiester bond hydrolysis, endonucleolytic • tRNA processing • protein lipoylation • tRNA 5'-leader removal • rRNA processing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51367	117109
Ensembl	ENSG00000167272	ENSMUSG00000060152
UniProt	Q969H6	Q9DB28
RefSeq (mRNA)	NM_015918 NM_198201 NM_198202	NM_026398
RefSeq (protein)	NP_057002 NP_937845	NP_080674
Location (UCSC)	Chr 12: 120.58 – 120.58 Mb	Chr 5: 115.24 – 115.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000167272 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060152 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Eenennaam H, Lugtenberg D, Vogelzangs JH, van Venrooij WJ, Pruijn GJ (Aug 2001). "hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases". J Biol Chem. 276 (34): 31635–41. doi:10.1074/jbc.M103399200. PMID 11413139.
6. "Entrez Gene: POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• van Eenennaam H, Pruijn GJ, van Venrooij WJ (1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC 148449. PMID 10352175.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822. PMID 15096576.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.