POLR1B

DNA-directed RNA polymerase I subunit RPA2 is an enzyme that in humans is encoded by the POLR1B gene.[5]

POLR1B
Identifiers
Aliases	POLR1B, RPA135, RPA2, Rpo1-2, polymerase (RNA) I subunit B, RNA polymerase I subunit B, A135
External IDs	OMIM: 602000 MGI: 108014 HomoloGene: 7133 GeneCards: POLR1B
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 112,541,915 bp[1] End 112,579,818 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 F1 Start 129,100,995 bp[2] End 129,126,594 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • DNA binding • nucleotidyltransferase activity • ribonucleoside binding • metal ion binding • DNA-directed 5'-3' RNA polymerase activity • GO:0001948 protein binding • RNA polymerase I activity Cellular component • nucleoplasm • nucleolus • DNA-directed RNA polymerase I complex • cell nucleus • cytosol Biological process • termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • transcription initiation from RNA polymerase I promoter • rRNA transcription • transcription, DNA-templated • embryo implantation • nucleologenesis • transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84172	20017
Ensembl	ENSG00000125630	ENSMUSG00000027395
UniProt	Q9H9Y6	P70700
RefSeq (mRNA)	NM_019014 NM_001137604 NM_001282772 NM_001282774 NM_001282776 NM_001282777 NM_001282779 NM_001371969 NM_001371970 NM_001371971	NM_009086
RefSeq (protein)	NP_001131076 NP_001269701 NP_001269703 NP_001269705 NP_001269706 NP_001269708 NP_061887 NP_001358898 NP_001358899 NP_001358900	NP_033112
Location (UCSC)	Chr 2: 112.54 – 112.58 Mb	Chr 2: 129.1 – 129.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000125630 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027395 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa".

Further reading

• Seither P, Zatsepina O, Hoffmann M, Grummt I (1997). "Constitutive and strong association of PAF53 with RNA polymerase I.". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID 9254723.
• Miller G, Panov KI, Friedrich JK (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
• Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I". Biol. Chem. 382 (8): 1163–70. doi:10.1515/BC.2001.146. PMID 11592397.
• Shiau AK, Barstad D, Radek JT (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. doi:10.1038/nsb787. PMID 11953755.
• Egea PF, Mitschler A, Moras D (2002). "Molecular recognition of agonist ligands by RXRs". Mol. Endocrinol. 16 (5): 987–97. doi:10.1210/me.16.5.987. PMID 11981034.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Yamamoto K, Yamamoto M, Hanada K (2004). "Multiple Protein-Protein Interactions by RNA Polymerase I-Associated Factor PAF49 and Role of PAF49 in rRNA Transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
• Philimonenko VV, Zhao J, Iben S (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034.
• Hillier LW, Graves TA, Fulton RS (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Zhang C, Comai L, Johnson DL (2005). "PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC 1190253. PMID 16055704.
• Percipalle P, Fomproix N, Cavellán E (2006). "The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.
• Panova TB, Panov KI, Russell J, Zomerdijk JC (2006). "Casein Kinase 2 Associates with Initiation-Competent RNA Polymerase I and Has Multiple Roles in Ribosomal DNA Transcription". Mol. Cell. Biol. 26 (16): 5957–68. doi:10.1128/MCB.00673-06. PMC 1592790. PMID 16880508.
• Johnson SS, Zhang C, Fromm J (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi:10.1016/j.molcel.2007.03.021. PMID 17499043.