POLR1A

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene.[5][6]

POLR1A
Identifiers
Aliases	POLR1A, A190, RPA1, RPA194, RPO1-4, RPO14, AFDCIN, polymerase (RNA) I subunit A, RNA polymerase I subunit A
External IDs	OMIM: 616404 MGI: 1096397 HomoloGene: 7033 GeneCards: POLR1A
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p11.2 Start 86,020,216 bp[1] End 86,106,155 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C1|6 32.21 cM Start 71,909,053 bp[2] End 71,984,935 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • DNA binding • nucleotidyltransferase activity • zinc ion binding • metal ion binding • DNA-directed 5'-3' RNA polymerase activity • GO:0001948 protein binding • RNA polymerase I activity • chromatin binding Cellular component • nucleoplasm • DNA-directed RNA polymerase I complex • cell nucleus • nucleolus Biological process • termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • transcription initiation from RNA polymerase I promoter • transcription, DNA-templated • negative regulation of protein localization to nucleolus • transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25885	20019
Ensembl	ENSG00000068654	ENSMUSG00000049553
UniProt	O95602	O35134
RefSeq (mRNA)	NM_015425	NM_009088
RefSeq (protein)	NP_056240	NP_033114
Location (UCSC)	Chr 2: 86.02 – 86.11 Mb	Chr 6: 71.91 – 71.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000068654 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049553 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seither P, Coy JF, Pouska A, Grummt I (Aug 1997). "Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I". Mol Gen Genet. 255 (2): 180–6. doi:10.1007/s004380050487. PMID 9236775.
6. "Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa".

Further reading

• Zhu L, Perlaky L, Henning D, Valdez BC (1998). "Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family". Biochem. Mol. Biol. Int. 42 (5): 927–35. doi:10.1080/15216549700203371. PMID 9285060.
• Chen HK, Pai CY, Huang JY, Yeh NH (2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol. Cell. Biol. 19 (12): 8536–46. doi:10.1128/mcb.19.12.8536. PMC 84972. PMID 10567578.
• Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
• Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
• Dundr M, Hoffmann-Rohrer U, Hu Q, et al. (2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Percipalle P, Fomproix N, Cavellán E, et al. (2006). "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.