PLD5

Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene.[5]

PLD5
Identifiers
Aliases	PLD5, PLDC, phospholipase D family member 5
External IDs	MGI: 2442056 HomoloGene: 16081 GeneCards: PLD5
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q43 Start 242,082,986 bp[1] End 242,524,697 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 175,962,306 bp[2] End 176,275,312 bp[2]
Orthologs
Species	Human	Mouse
Entrez	200150	319455
Ensembl	ENSG00000180287	ENSMUSG00000055214
UniProt	Q8N7P1	Q3UNN8
RefSeq (mRNA)	NM_001195811 NM_001195812 NM_152666 NM_001320272 NM_001372062	NM_001195816 NM_176916 NM_001357844 NM_001357845 NM_001357846 NM_001357847
RefSeq (protein)	NP_001182740 NP_001182741 NP_001307201 NP_001358991	NP_001182745 NP_795890 NP_001344773 NP_001344774 NP_001344775 NP_001344776
Location (UCSC)	Chr 1: 242.08 – 242.52 Mb	Chr 1: 175.96 – 176.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Model organisms

Pld5 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal[6]
Citrobacter infection	Normal[7]
All tests and analysis from[8][9]

Model organisms have been used in the study of PLD5 function. A conditional knockout mouse line, called Pld5^{tm1a(KOMP)Wtsi}[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000180287 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055214 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PLD5 phospholipase D family, member 5". Retrieved 2011-12-04.
6. "Salmonella infection data for Pld5". Wellcome Trust Sanger Institute.
7. "Citrobacter infection data for Pld5". Wellcome Trust Sanger Institute.
8. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
9. Mouse Resources Portal, Wellcome Trust Sanger Institute.
10. "International Knockout Mouse Consortium".
11. "Mouse Genome Informatics".
12. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
13. Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
14. Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
15. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

• Anney, R.; Klei, L.; Pinto, D.; Regan, R.; Conroy, J.; Magalhaes, T. R.; Correia, C.; Abrahams, B. S.; Sykes, N.; Pagnamenta, A. T.; Almeida, J.; Bacchelli, E.; Bailey, A. J.; Baird, G.; Battaglia, A.; Berney, T.; Bolshakova, N.; Bölte, S.; Bolton, P. F.; Bourgeron, T.; Brennan, S.; Brian, J.; Carson, A. R.; Casallo, G.; Casey, J.; Chu, S. H.; Cochrane, L.; Corsello, C.; Crawford, E. L.; et al. (2010). "A genome-wide scan for common alleles affecting risk for autism". Human Molecular Genetics. 19 (20): 4072–4082. doi:10.1093/hmg/ddq307. PMC 2947401. PMID 20663923.
• Rose, J.; Behm, F.; Drgon, T.; Johnson, C.; Uhl, G. R. (2010). "Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score". Molecular Medicine. 16 (7–8): 247–253. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• McCauley, J. L.; Zuvich, R. L.; Bradford, Y.; Kenealy, S. J.; Schnetz-Boutaud, N.; Gregory, S. G.; Hauser, S. L.; Oksenberg, J. R.; Mortlock, D. P.; Pericak-Vance, M. A.; Haines, J. L. (2009). "Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis". Genes and Immunity. 10 (7): 624–630. doi:10.1038/gene.2009.53. PMC 2765552. PMID 19626040.