PHLDB2

Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.[5][6]

PHLDB2
Identifiers
Aliases	PHLDB2, LL5b, LL5beta, pleckstrin homology like domain family B member 2
External IDs	OMIM: 610298 MGI: 2444981 HomoloGene: 17100 GeneCards: PHLDB2
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.2 Start 111,732,497 bp[1] End 111,976,517 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B5 Start 45,746,243 bp[2] End 45,953,598 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • cadherin binding Cellular component • cell membrane • intermediate filament cytoskeleton • basal cortex • cell leading edge • membrane • focal adhesion • cytoplasm • cytosol Biological process • negative regulation of wound healing, spreading of epidermal cells • regulation of epithelial to mesenchymal transition • regulation of microtubule cytoskeleton organization • positive regulation of basement membrane assembly involved in embryonic body morphogenesis • negative regulation of stress fiber assembly • regulation of gastrulation • microtubule cytoskeleton organization • negative regulation of focal adhesion assembly • establishment of protein localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90102	208177
Ensembl	ENSG00000144824	ENSMUSG00000033149
UniProt	Q86SQ0	Q8K1N2
RefSeq (mRNA)	NM_145753 NM_001134437 NM_001134438 NM_001134439	NM_001252442 NM_153412 NM_001357078
RefSeq (protein)	NP_001127909 NP_001127910 NP_001127911 NP_665696	NP_001239371 NP_700461 NP_001344007
Location (UCSC)	Chr 3: 111.73 – 111.98 Mb	Chr 16: 45.75 – 45.95 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PHLDB2 has been shown to interact with FLNC.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000144824 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033149 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem. 278 (2): 1328–35. doi:10.1074/jbc.M208352200. PMID 12376540.
6. "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".

Further reading

• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.