PHF2

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.[5]

PHF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KQI, 3PTR, 3PU3, 3PU8, 3PUA, 3PUS
Identifiers
Aliases	PHF2, CENP-35, GRC5, JHDM1E, PHD finger protein 2, KDM7C
External IDs	OMIM: 604351 MGI: 1338034 HomoloGene: 3934 GeneCards: PHF2
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.31 Start 93,576,584 bp[1] End 93,679,587 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 A5|13 24.96 cM Start 48,801,750 bp[2] End 48,871,119 bp[2]
Gene ontology Molecular function • iron ion binding • histone demethylase activity (H3-K9 specific) • GO:0001105 transcription coactivator activity • dioxygenase activity • metal ion binding • methylated histone binding • GO:0001948 protein binding • oxidoreductase activity • histone demethylase activity • zinc ion binding Cellular component • condensed chromosome kinetochore • nucleoplasm • chromosome • nucleolus • chromosome, centromeric region • kinetochore • cell nucleus Biological process • regulation of transcription, DNA-templated • histone H3-K9 demethylation • protein demethylation • transcription, DNA-templated • negative regulation of chromatin silencing at rDNA • liver development • oxidation-reduction process • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5253	18676
Ensembl	ENSG00000197724	ENSMUSG00000038025
UniProt	O75151	Q9WTU0
RefSeq (mRNA)	NM_005392 NM_024517	NM_011078
RefSeq (protein)	NP_005383	NP_035208
Location (UCSC)	Chr 9: 93.58 – 93.68 Mb	Chr 13: 48.8 – 48.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.

References

1. GRCh38: Ensembl release 89: ENSG00000197724 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038025 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PHD finger protein 2". Retrieved 2016-04-09.

Further reading

• Sinha S, Singh RK, Alam N, Roy A, Roychoudhury S, Panda CK (2008). "Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma". Mol. Cancer. 7: 84. doi:10.1186/1476-4598-7-84. PMC 2633285. PMID 18990233.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.