PCYOX1

Prenylcysteine oxidase 1 is an enzyme that in humans is encoded by the PCYOX1 gene.[5][6][7]

PCYOX1
Identifiers
Aliases	PCYOX1, PCL1, prenylcysteine oxidase 1
External IDs	OMIM: 610995 MGI: 1914131 HomoloGene: 9458 GeneCards: PCYOX1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 70,257,386 bp[1] End 70,281,185 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 86,386,006 bp[2] End 86,397,154 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • chloride-transporting ATPase activity • oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor • prenylcysteine oxidase activity Cellular component • cell membrane • extracellular exosome • vacuolar membrane • very-low-density lipoprotein particle • lysosome Biological process • prenylcysteine metabolic process • chloride transport • chloride transmembrane transport • oxidation-reduction process • prenylcysteine catabolic process • prenylated protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51449	66881
Ensembl	ENSG00000116005	ENSMUSG00000029998
UniProt	Q9UHG3	Q9CQF9
RefSeq (mRNA)	NM_016297	NM_025823 NM_001355687
RefSeq (protein)	NP_057381	NP_080099 NP_001342616
Location (UCSC)	Chr 2: 70.26 – 70.28 Mb	Chr 6: 86.39 – 86.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Prenylcysteine oxidase

References

1. GRCh38: Ensembl release 89: ENSG00000116005 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029998 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tschantz WR, Zhang L, Casey PJ (Jan 2000). "Cloning, expression, and cellular localization of a human prenylcysteine lyase". J Biol Chem. 274 (50): 35802–8. doi:10.1074/jbc.274.50.35802. PMID 10585463.
6. Digits JA, Pyun HJ, Coates RM, Casey PJ (Oct 2002). "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase". J Biol Chem. 277 (43): 41086–93. doi:10.1074/jbc.M208069200. PMID 12186880.
7. "Entrez Gene: PCYOX1 prenylcysteine oxidase 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Zhang L, Tschantz WR, Casey PJ (1997). "Isolation and characterization of a prenylcysteine lyase from bovine brain". J. Biol. Chem. 272 (37): 23354–9. doi:10.1074/jbc.272.37.23354. PMID 9287348.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Wouters MM, Neefs JM, Kerchove d'Exaerde A, et al. (2006). "Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum". Biochem. Biophys. Res. Commun. 346 (2): 491–500. doi:10.1016/j.bbrc.2006.05.132. PMID 16765319.