PCDHB11

Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene.[4][5]

PCDHB11
Identifiers
AliasesPCDHB11, ME2, PCDH-BETA11, protocadherin beta 11
External IDsOMIM: 606337 MGI: 2136759 HomoloGene: 134302 GeneCards: PCDHB11
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q31.3Start141,199,610 bp[1]
End141,203,779 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56125

93892

Ensembl

ENSG00000197479

n/a

UniProt

Q9Y5F2

Q91V48

RefSeq (mRNA)

NM_018931

NM_053146

RefSeq (protein)

NP_061754

NP_444376

Location (UCSC)Chr 5: 141.2 – 141.2 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000197479 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
  5. "Entrez Gene: PCDHB11 protocadherin beta 11".

Further reading


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