PCDH7

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.[5][6]

PCDH7
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2YST
Identifiers
Aliases	PCDH7, BH-Pcdh, BHPCDH, PPP1R120, protocadherin 7
External IDs	OMIM: 602988 MGI: 1860487 HomoloGene: 36101 GeneCards: PCDH7
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.1 Start 30,720,415 bp[1] End 31,146,805 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C1 Start 57,717,967 bp[2] End 58,133,230 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding Cellular component • integral component of membrane • cell membrane • integral component of plasma membrane • membrane • platelet alpha granule membrane Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • platelet degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5099	54216
Ensembl	ENSG00000169851	ENSMUSG00000029108
UniProt	O60245	n/a
RefSeq (mRNA)	NM_001173523 NM_002589 NM_032456 NM_032457	NM_001122758 NM_018764 NM_001310606 NM_001310608
RefSeq (protein)	NP_001166994 NP_002580 NP_115832 NP_115833	n/a
Location (UCSC)	Chr 4: 30.72 – 31.15 Mb	Chr 5: 57.72 – 58.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell–cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000169851 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029108 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics. 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233.
6. "Entrez Gene: PCDH7 protocadherin 7".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain". FEBS Lett. 460 (1): 93–8. doi:10.1016/S0014-5793(99)01309-5. PMID 10571067.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.