PCDH20

Protocadherin-20 is a protein that in humans is encoded by the PCDH20 gene.[5]

PCDH20
Identifiers
Aliases	PCDH20, PCDH13, protocadherin 20
External IDs	OMIM: 614449 MGI: 2443376 HomoloGene: 11277 GeneCards: PCDH20
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q21.2 Start 61,409,685 bp[1] End 61,415,522 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E1 Start 88,464,743 bp[2] End 88,471,396 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • RNA binding Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64881	219257
Ensembl	ENSG00000280165	ENSMUSG00000050505
UniProt	Q8N6Y1	Q8BIZ0
RefSeq (mRNA)	NM_022843	NM_178685
RefSeq (protein)	NP_073754	NP_848800
Location (UCSC)	Chr 13: 61.41 – 61.42 Mb	Chr 14: 88.46 – 88.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000280165 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050505 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PCDH20 protocadherin 20".

Further reading

• Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
• Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.