PARD3B

Partitioning defective 3 homolog B is a protein that in humans is encoded by the PARD3B gene.[5][6][7]

PARD3B
Identifiers
Aliases	PARD3B, ALS2CR19, PAR3B, PAR3L, PAR3LC, PAR3beta, Par3Lb, par-3 family cell polarity regulator beta
External IDs	MGI: 1919301 HomoloGene: 35389 GeneCards: PARD3B
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 204,545,475 bp[1] End 205,620,162 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C2 Start 61,638,824 bp[2] End 62,642,284 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding • phosphatidylinositol binding Cellular component • membrane • endomembrane system • bicellular tight junction • cell junction • nucleoplasm • nuclear body • macromolecular complex • cytoplasm • adherens junction • cell cortex • apical plasma membrane • apical junction complex Biological process • cell division • cell cycle • microtubule cytoskeleton organization • cell adhesion • protein localization • establishment of cell polarity • establishment or maintenance of epithelial cell apical/basal polarity • establishment of centrosome localization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117583	72823
Ensembl	ENSG00000116117	ENSMUSG00000052062
UniProt	Q8TEW8	Q9CSB4
RefSeq (mRNA)	NM_001302769 NM_057177 NM_152526 NM_205863	NM_001081050
RefSeq (protein)	NP_001289698 NP_476518 NP_689739 NP_995585	NP_001074519
Location (UCSC)	Chr 2: 204.55 – 205.62 Mb	Chr 1: 61.64 – 62.64 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PARD3B has been shown to interact with Mothers against decapentaplegic homolog 3.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000116117 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052062 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler BA, Sagie T, Skaug J, Nasir J, Brown RH Jr, Scherer SW, Rouleau GA, Hayden MR, Ikeda JE (Oct 2001). "A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2". Nat Genet. 29 (2): 166–73. doi:10.1038/ng1001-166. PMID 11586298.
6. Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem Biophys Res Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
7. "Entrez Gene: PARD3B par-3 partitioning defective 3 homolog B (C. elegans)".
8. Warner, Dennis R; Pisano M Michele; Roberts Emily A; Greene Robert M (Mar 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. Netherlands. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. ISSN 0014-5793. PMID 12650946.

Further reading

• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Izaki T, Kamakura S, Kohjima M, Sumimoto H (2005). "Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein". Biochem. Biophys. Res. Commun. 329 (1): 211–8. doi:10.1016/j.bbrc.2005.01.115. PMID 15721295.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.